50 years of proven safety & efficacy1, 2
|1.||Data on file. Ethicon, Inc.|
|2.||Surgicel Absorbable Hemostat Full Prescribing Information|
|3.||Spangler D, et al. In Vitro Antimicrobial Activity of Oxidized Regenerated Cellulose against antibiotic-resistant microorganisms. Surgical Infection, 2003; 4(3):255-262.|
Proven Bactericidal Advantage
SURGICEL® Absorbable Hemostat is the first and only absorbable hemostat that is proven bactericidal against a broad range of gram-positive and gram-negative organisms including various antibiotic resistant bacteria (MRSA, VRE, PRSP and MRSE)†1,2
In vivo animal studies have proven SURGICEL® Absorbable Hemostats, in contrast to other hemostatic agents studied, do not enhance infection.4-7
The experimental model: 140 guinea pigs were utilized to simulate the development of intra-abdominal abscess and/or peritonitis, which can occur in humans when a large blood clot becomes contaminated.
†Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), penicillin-resistant Streptococcus pneumoniae (PRSP), methicillin-resistant Staphylococcus epidermidis (MRSE).
‡CFU=Colony Forming Units
Clinical significance of these animal or in vitro data has yet to be determined.
Closing SURGICEL® Absorbable Hemostat in a contaminated wound without drainage may lead to complications and should be avoided.
|1.||Spangler D, et al. In Vitro Antimicrobial Activity of Oxidized Regenerated Cellulose against antibiotic-resistant microorganisms. Surgical Infection, 2003; 4(3):255-262.|
|2.||Data on file, in vivo study. Ethicon, Inc.|
|3.||Spangler D. Rothenburger S, Nguyen K, Jampani H, Weiss S, Bhende S. In vitro antimicrobial activity of oxidized regenerated cellulose against antibiotic-resistant microorganisms. Surg Infect. 2003;4(3):255-262.|
|4.||Kuchta, Dineen.Effects of Absorbable Hemostats on Intraabdominal Sepsis. Infections in Surgery. 1983;441: 444.|
|5.||Dineen P. The effect of Oxidized Regenerated Cellulose on experimental Infected Splenotomies. Journal of Surgical Research .23, pp 114 – 116.|
|6.||Dineen, P. Antibacterial activity of oxidized regenerated cellulose. Surgery, Gynecology and Obstretrics. 1976;142:481-486.|
|7.||Dineen, P. The effect of oxidized regenerated cellulose on experimental intravascular infecton. Surgery. 1977;82:576-579.|