Specialties
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SURGICEL^® NU-KNIT^® Absorbable Hemostat

About the Product
Clinical Information
Professional Resources
Related Information

STRENGTH
High tensile strength for heavier bleeding¹

Dense knit material provides strength in the presence of heavy bleeding¹
Soft, pliable weave designed to hold a suture2 and for placement on delicate tissue³
3 times more dense than SURGICEL® Original Absorbable Hemostat—36% faster time to hemostasis¹
Proven bactericidal properties^1,3,4
Ideal for trauma, sternotomies, and solid organ procedures

http://www.ethicon360.com/sites/default/files/JJ Letter.pdf

http://www.ethicon360.com/sites/default/files/Core_Brochure_Surgicel.pdf

References
1.	Data on file. Ethicon, Inc.
2.	Mair H, Kaczemared I, Oberhoffer M, Groetzner J, Daebritz S, Reichart B. Surgicel Nu-knit hemostat for bleeding control of fragile sternum. J Thorac Cardiovasc Surg. 2005; 130(2):605-606.
3.	Surgicel Absorbable Hemostat Full Prescribing Information
4.	Spangler D, et al. In Vitro Antimicrobial Activity of Oxidized Regenerated Cellulose against antibiotic-resistant microorganisms. Surgical Infection, 2003; 4(3):255-262.

SURGICEL® NU-KNIT® Absorbable Hemostats

	SURGICEL® Absorbable Hemostat Literature Compendium Overview
	This clinical article provides additional clinical information related to the use of SURGICEL® Family of Absorbable Hemostats.

Proven Bactericidal Advantage

SURGICEL^® Absorbable Hemostat is the first and only absorbable hemostat that is proven bactericidal against a broad range of gram-positive and gram-negative organisms including various antibiotic resistant bacteria (MRSA, VRE, PRSP and MRSE)^†1,2

SUGICEL MRSA Logarithmic Reduction

In vivo animal studies have proven SURGICEL^® Absorbable Hemostats, in contrast to other hemostatic agents studied, do not enhance infection.^4-7

SUGICEL Surcicing Population

The experimental model: 140 guinea pigs were utilized to simulate the development of intra-abdominal abscess and/or peritonitis, which can occur in humans when a large blood clot becomes contaminated.

†Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), penicillin-resistant Streptococcus pneumoniae (PRSP), methicillin-resistant Staphylococcus epidermidis (MRSE).

‡CFU=Colony Forming Units

Clinical significance of these animal or in vitro data has yet to be determined.

Closing SURGICEL^® Absorbable Hemostat in a contaminated wound without drainage may lead to complications and should be avoided.

References
1.	Spangler D, et al. In Vitro Antimicrobial Activity of Oxidized Regenerated Cellulose against antibiotic-resistant microorganisms. Surgical Infection, 2003; 4(3):255-262.
2.	Data on file, in vivo study. Ethicon, Inc.
3.	Spangler D. Rothenburger S, Nguyen K, Jampani H, Weiss S, Bhende S. In vitro antimicrobial activity of oxidized regenerated cellulose against antibiotic-resistant microorganisms. Surg Infect. 2003;4(3):255-262.
4.	Kuchta, Dineen.Effects of Absorbable Hemostats on Intraabdominal Sepsis. Infections in Surgery. 1983;441: 444.
5.	Dineen P. The effect of Oxidized Regenerated Cellulose on experimental Infected Splenotomies. Journal of Surgical Research .23, pp 114 – 116.
6.	Dineen, P. Antibacterial activity of oxidized regenerated cellulose. Surgery, Gynecology and Obstretrics. 1976;142:481-486.
7.	Dineen, P. The effect of oxidized regenerated cellulose on experimental intravascular infecton. Surgery. 1977;82:576-579.